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Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2017 Jun; Vol. 1398 (1), pp. 108-119. - Publication Year :
- 2017
-
Abstract
- Cucurbit[7]uril (CB[7]), belonging to the cucurbit[n]uril family (CB[n], n = 5-8, 10, or 13-15), may form host-guest complexes with a variety of small molecules of biomedical interest. The physical and chemical properties of the complexed drugs are often improved as a result of this complexation, suggesting the potential application of CB[7] as a pharmaceutical excipient. This review has summarized the most recent research progress reported between 2011 and early 2017 regarding the biocompatibility of CB[7] and the influence of CB[7] on the stability, solubility, biouptake, and biological activities (including therapeutic efficacies and toxicities) of guest drug molecules. Through this systemic summary and analysis, we intend to stimulate further research efforts in this area and promote the use of CB[7] as an emerging pharmaceutical excipient to improve various properties of drug molecules (or active pharmaceutical ingredients).<br /> (© 2017 New York Academy of Sciences.)
- Subjects :
- Bridged-Ring Compounds chemistry
Excipients chemistry
Humans
Imidazoles chemistry
Molecular Structure
Small Molecule Libraries chemistry
Small Molecule Libraries therapeutic use
Bridged-Ring Compounds therapeutic use
Drug Delivery Systems
Excipients therapeutic use
Imidazoles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1398
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28692768
- Full Text :
- https://doi.org/10.1111/nyas.13376