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Impact of Work Task-Related Acute Occupational Smoke Exposures on Select Proinflammatory Immune Parameters in Wildland Firefighters.
- Source :
-
Journal of occupational and environmental medicine [J Occup Environ Med] 2017 Jul; Vol. 59 (7), pp. 679-690. - Publication Year :
- 2017
-
Abstract
- Objective: A repeated measures study was used to assess the effect of work tasks on select proinflammatory biomarkers in firefighters working at prescribed burns.<br />Methods: Ten firefighters and two volunteers were monitored for particulate matter and carbon monoxide on workdays, January to July 2015. Before and after workshift dried blood spots were analyzed for inflammatory mediators using the Meso Scale Discovery assay, while blood smears were used to assess leukocyte parameters.<br />Results: Firefighters lighting with drip-torches had higher cross-work-shift increases in interleukin-8, C-reactive protein, and serum amyloid A compared with holding, a task involving management of fire boundaries. A positive association between interleukin-8 and segmented-neutrophil was observed.<br />Conclusion: Results from this study suggest that intermittent occupational diesel exposures contribute to cross-work-shift changes in host systemic innate inflammation as indicated by elevated interleukin-8 levels and peripheral blood segmented-neutrophils.
- Subjects :
- Adult
Air Pollutants, Occupational adverse effects
Biomarkers blood
Carbon Monoxide adverse effects
Dried Blood Spot Testing
Female
Humans
Inhalation Exposure adverse effects
Male
Neutrophils pathology
Particulate Matter adverse effects
Amyloid blood
C-Reactive Protein metabolism
Firefighters
Interleukin-8 blood
Occupational Exposure adverse effects
Smoke adverse effects
Wildfires
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5948
- Volume :
- 59
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of occupational and environmental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28692002
- Full Text :
- https://doi.org/10.1097/JOM.0000000000001053