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Development of tetrahydrobiopterin and GTP cyclohydrolase in salivary glands of rats.
- Source :
-
The International journal of biochemistry [Int J Biochem] 1986; Vol. 18 (2), pp. 131-5. - Publication Year :
- 1986
-
Abstract
- A significant amount of 5,6,7,8-tetrahydrobiopterin (BH4), an essential cofactor of tyrosine hydroxylase, and the activity of GTP cyclohydrolase (GTP cycl), the first and rate-limiting enzyme in BH4 biosynthesis, were found in rat salivary glands, in which adrenergic transmitters are localized, from day 4 through 56 after birth. About 90 ng of BH4 per g wet weight were determined in the glands (submandibular and sublingual) of adult rats. The levels of them which were maintained from 2 weeks after birth up to the adult stage correlated with a previous finding in the maintenance of catecholamine concentration during the same stage in rat salivary glands.
Details
- Language :
- English
- ISSN :
- 0020-711X
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The International journal of biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 2868934
- Full Text :
- https://doi.org/10.1016/0020-711x(86)90144-8