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The influence of intrinsic sympathomimetic activity and beta-1 receptor selectivity on the recovery of finger skin temperature after finger cooling in normotensive subjects.
- Source :
-
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 1986 Mar; Vol. 39 (3), pp. 353-7. - Publication Year :
- 1986
-
Abstract
- A double-blind randomized study was designed to investigate differences in the recovery of finger skin temperature after finger cooling during dosing with placebo or one of four beta-blockers: propranolol, atenolol, pindolol, and acebutolol. In 11 normotensive nonsmoking subjects, finger skin temperature was measured with a thermocouple before and 20 minutes after immersion of one hand in a water bath at 16 degrees C. This finger cooling test caused no significant changes in systemic hemodynamics such as arterial blood pressure, heart rate, and forearm blood flow. The recovery of finger skin temperature during propranolol dosing was better than that during pindolol and atenolol dosing. There were no differences between the recoveries of skin temperature during pindolol, atenolol, and acebutolol dosing. Thus we could demonstrate no favorable effect of intrinsic sympathomimetic activity or beta 1-selectivity on the recovery of finger skin temperature after finger cooling.
- Subjects :
- Acebutolol pharmacology
Administration, Oral
Adult
Atenolol pharmacology
Blood Pressure drug effects
Double-Blind Method
Drug Evaluation
Female
Fingers
Forearm blood supply
Heart Rate drug effects
Humans
Male
Pindolol pharmacology
Propranolol pharmacology
Random Allocation
Adrenergic beta-Antagonists pharmacology
Cold Temperature
Skin Temperature drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9236
- Volume :
- 39
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 2868824
- Full Text :
- https://doi.org/10.1038/clpt.1986.52