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Virus-Triggered ATP Release Limits Viral Replication through Facilitating IFN-β Production in a P2X7-Dependent Manner.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Aug 15; Vol. 199 (4), pp. 1372-1381. Date of Electronic Publication: 2017 Jul 07. - Publication Year :
- 2017
-
Abstract
- Accumulating evidence shows that innate immune responses are associated with extracellular nucleotides, particularly ATP. In this article, we demonstrate extensive protection of ATP/P2X7 signaling in a host against viral infection. Interestingly, we observed a significant increase in ATP as a danger signal in vesicular stomatitis virus (VSV)-infected cell supernatant and VSV-infected mice in an exocytosis- and pannexin channel-dependent manner. Furthermore, extracellular ATP reduces the replication of VSV, Newcastle disease virus, murine leukemia virus, and HSV in vivo and in vitro through the P2X7 receptor. Meanwhile, ATP significantly increases IFN-β expression in a concentration- and time-dependent manner. Mechanistically, ATP facilitates IFN-β secretion through P38/JNK/ATF-2 signaling pathways, which are crucial in promoting antiviral immunity. Taken together, these results demonstrate the protective role of extracellular ATP and P2X7 in viral infection and suggest a potential therapeutic role for ATP/P2X7 in viral diseases.<br /> (Copyright © 2017 by The American Association of Immunologists, Inc.)
- Subjects :
- Adenosine Triphosphate pharmacology
Animals
Immunity, Innate
Interferon-beta genetics
Interferon-beta immunology
Leukemia Virus, Murine drug effects
Leukemia Virus, Murine immunology
Luminescent Measurements
Mice
Newcastle disease virus drug effects
Newcastle disease virus immunology
RAW 264.7 Cells
Receptors, Purinergic P2X7 immunology
Signal Transduction
Simplexvirus drug effects
Simplexvirus immunology
Vesicular Stomatitis virology
Vesicular stomatitis Indiana virus drug effects
Vesicular stomatitis Indiana virus immunology
Virus Replication drug effects
Adenosine Triphosphate metabolism
Interferon-beta biosynthesis
Receptors, Purinergic P2X7 metabolism
Vesicular Stomatitis immunology
Vesicular stomatitis Indiana virus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 199
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 28687662
- Full Text :
- https://doi.org/10.4049/jimmunol.1700187