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Anti-biofilm properties of a mupirocin spray formulation against Escherichia coli wound infections.
- Source :
-
Biofouling [Biofouling] 2017 Aug; Vol. 33 (7), pp. 591-600. Date of Electronic Publication: 2017 Jul 07. - Publication Year :
- 2017
-
Abstract
- Mupirocin ointment is a widely used topical drug for the treatment of bacterial skin infections. However, ointments have some limitations which motivated the development of a film forming spray of mupirocin. Mupirocin spray (2%) was formulated with Eudragit E100 as a film forming agent and tested for its antibacterial and anti-biofilm activities against Escherichia coli, a skin pathogen causing wound and surgical site infections. Treatment with mupirocin spray resulted in significant antibacterial and anti-biofilm activities (inhibition and disruption) with single spray and sub-actual dose concentrations at par with the commercial ointment concentration. The spray formulation was found to be non-toxic to fibroblast cells and greatly resisted removal from the site of application upon washing, in contrast to the ointment which was significantly removed after a single wash. This is the first study to develop and evaluate a spray formulation for mupirocin that forms a stable thin film for sustained release of the drug.
- Subjects :
- Acrylates chemistry
Administration, Cutaneous
Aerosols
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents toxicity
Cell Line
Cell Survival drug effects
Drug Compounding
Escherichia coli isolation & purification
Humans
Mupirocin administration & dosage
Mupirocin toxicity
Ointments
Polymers chemistry
Anti-Bacterial Agents pharmacology
Biofilms drug effects
Escherichia coli drug effects
Mupirocin pharmacology
Skin Diseases, Bacterial drug therapy
Staphylococcal Infections drug therapy
Wound Infection drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2454
- Volume :
- 33
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biofouling
- Publication Type :
- Academic Journal
- Accession number :
- 28686044
- Full Text :
- https://doi.org/10.1080/08927014.2017.1337100