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Modeling human disease in rodents by CRISPR/Cas9 genome editing.
- Source :
-
Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2017 Aug; Vol. 28 (7-8), pp. 291-301. Date of Electronic Publication: 2017 Jul 04. - Publication Year :
- 2017
-
Abstract
- Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.
- Subjects :
- Animals
Animals, Genetically Modified
Disease Models, Animal
Genetic Therapy methods
Genetic Variation
Genomics methods
Humans
Mice
Multifactorial Inheritance
Open Reading Frames
Precision Medicine
RNA, Untranslated
Regulatory Sequences, Ribonucleic Acid
CRISPR-Cas Systems
Gene Editing
Genetic Association Studies methods
Genetic Predisposition to Disease
Models, Biological
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1777
- Volume :
- 28
- Issue :
- 7-8
- Database :
- MEDLINE
- Journal :
- Mammalian genome : official journal of the International Mammalian Genome Society
- Publication Type :
- Academic Journal
- Accession number :
- 28677007
- Full Text :
- https://doi.org/10.1007/s00335-017-9703-x