Back to Search
Start Over
Impact of the biomolecular corona on the structure of PEGylated liposomes.
- Source :
-
Biomaterials science [Biomater Sci] 2017 Aug 22; Vol. 5 (9), pp. 1884-1888. - Publication Year :
- 2017
-
Abstract
- Driven by the promises of gene therapy, PEGylated cationic liposomes (CLs) have been investigated for decades, but their use in the clinical setting is far from established. Such a dichotomy is due to several factors that have been ignored over the last two decades. The hardest challenge seems to occur when PEGylated CLs come into contact with a physiological environment (e.g. the blood). Recent evidence has demonstrated that PEGylation does not completely prevent protein binding (as believed so far), but a biomolecular shell, termed "biomolecular corona" (BC), covers the liposome surface. Here we show that the formation of a BC not only affects the surface properties of PEGylated CLs, but also, and significantly, their bilayer structure thus impairing their ability to safely deliver their cargo to the target site. Therefore, a mechanistic understanding of the structures emerging from liposome-protein interactions may represent a truly new paradigm for the clinical translation of PEGylated CLs.
Details
- Language :
- English
- ISSN :
- 2047-4849
- Volume :
- 5
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biomaterials science
- Publication Type :
- Academic Journal
- Accession number :
- 28676869
- Full Text :
- https://doi.org/10.1039/c7bm00387k