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Heart Failure with Preserved Ejection Fraction: Entresto a Possible Option.
- Source :
-
Cardiovascular & hematological disorders drug targets [Cardiovasc Hematol Disord Drug Targets] 2017; Vol. 17 (2), pp. 80-85. - Publication Year :
- 2017
-
Abstract
- Background: Heart failure with preserved ejection fraction (HFpEF) makes up half of diagnosed heart failure (HF) cases and has similar outcomes compared to heart failure with reduced ejection fraction (HFrEF) but a discrepancy in knowledge and approach to treatment. HFpEF is diagnosed using the following criteria: symptoms, preserved ejection fraction (greater than 50%), and evidence of abnormal left ventricular filling or relaxation, or diastolic distensibility or stiffness. Studies conducted to examine the efficacy of angiotensin receptor blockers (ARB) (irbesartan and candesartan), thiazide diuretics (chlorthalidone), and angiotensin converting enzyme inhibitors (ACEI) (perindopril) in the treatment of HFpEF, showed moderate efficacy but no clear benefit. Recently, the FDA has approved a novel drug, which combines an angiotensin receptor neprilysin inhibitor and ARB (valsartan) named LCZ696 (entresto) for possible treatment of HFrEF.<br />Conclusion: In this article, we will discuss the failure of previous treatment modalities and the promise that LCZ696 (entresto) may hold for treating patients with HFpEF.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Subjects :
- Aminobutyrates pharmacokinetics
Angiotensin Receptor Antagonists pharmacokinetics
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Animals
Antihypertensive Agents therapeutic use
Benzimidazoles therapeutic use
Biphenyl Compounds therapeutic use
Clinical Trials as Topic
Drug Combinations
Heart physiopathology
Heart Failure physiopathology
Humans
Irbesartan
Perindopril therapeutic use
Tetrazoles pharmacokinetics
Valsartan
Aminobutyrates therapeutic use
Angiotensin Receptor Antagonists therapeutic use
Heart drug effects
Heart Failure diagnosis
Heart Failure drug therapy
Tetrazoles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2212-4063
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cardiovascular & hematological disorders drug targets
- Publication Type :
- Academic Journal
- Accession number :
- 28676030
- Full Text :
- https://doi.org/10.2174/1871529X17666170703120237