Superoxide Dismutase-Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain.

Authors :: Kartha S
Yan L
Weisshaar CL
Ita ME
Shuvaev VV
Muzykantov VR
Tsourkas A
Winkelstein BA
Cheng Z
Source :: Advanced healthcare materials [Adv Healthc Mater] 2017 Sep; Vol. 6 (17). Date of Electronic Publication: 2017 Jul 03.
Publication Year :: 2017
Abstract: A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated antioxidant enzyme SOD. In vivo studies in the rat demonstrate that administration of SOD-encapsulated porous polymersomes can prevent neuropathic pain after nerve root compression more effectively than treatment with free antioxidant enzyme alone.<br /> (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Antioxidants pharmacology
Male
Neuralgia pathology
Pain Threshold
Porosity
Radiculopathy drug therapy
Radiculopathy pathology
Rats
Antioxidants therapeutic use
Neuralgia drug therapy
Polymers chemistry
Superoxide Dismutase metabolism

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