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Mood and neural correlates of excessive daytime sleepiness in Parkinson's disease.
- Source :
-
Acta neurologica Scandinavica [Acta Neurol Scand] 2017 Aug; Vol. 136 (2), pp. 84-96. Date of Electronic Publication: 2016 Nov 07. - Publication Year :
- 2017
-
Abstract
- For patients with Parkinson's disease (PD), excessive daytime sleepiness (PD-EDS) is a debilitating non-motor symptom and may be affected by mood symptoms, especially depression and anxiety. Few neuroimaging works have attempted to identify the neural features of PD-EDS, but various findings were reported. The purpose of this study was to systematically review the literature on mood and neuroimaging correlates of PD-EDS. A MEDLINE, PubMed, EMBASE, and PsycInfo search for peer-reviewed original research articles on depression, anxiety, and neuroimaging in PD-EDS identified 26 studies on depression, nine on anxiety, and eight on neuroimaging. Half of the studies reported greater depression in PD-EDS-positive patients compared with PD-EDS-negative patients. There was a significantly positive correlation between depression and PD-EDS. Limited studies on anxiety in PD-EDS suggested a weak correlation between anxiety and EDS. For depression and anxiety, the effect sizes were medium when EDS was subjectively measured, but became small when EDS was objective measured. Current neuroimaging studies generally suggested diminished neural structural and functional features (eg, brain volume, white matter integrity as indicated by fractional anisotropy, and cerebral metabolism) in patients with PD-EDS. Future studies should apply objective and subjective measures of mood symptoms and EDS and improve the neuroimaging methodology via using multimodal techniques and whole-brain analysis to provide new clues on the mood and neural correlates of PD-EDS.<br /> (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Aged
Anxiety diagnostic imaging
Anxiety physiopathology
Anxiety psychology
Brain physiopathology
Depression diagnostic imaging
Depression physiopathology
Depression psychology
Disorders of Excessive Somnolence physiopathology
Female
Humans
Male
Middle Aged
Neuroimaging methods
Parkinson Disease physiopathology
White Matter diagnostic imaging
White Matter physiopathology
Affect
Brain diagnostic imaging
Disorders of Excessive Somnolence diagnostic imaging
Disorders of Excessive Somnolence psychology
Parkinson Disease diagnostic imaging
Parkinson Disease psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0404
- Volume :
- 136
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta neurologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 28670700
- Full Text :
- https://doi.org/10.1111/ane.12704