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Grey matter density changes of structures involved in Posttraumatic Stress Disorder (PTSD) after recovery following Eye Movement Desensitization and Reprocessing (EMDR) therapy.
- Source :
-
Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2017 Aug 30; Vol. 266, pp. 146-152. Date of Electronic Publication: 2017 Jun 19. - Publication Year :
- 2017
-
Abstract
- Recovery of stress-induced structural alterations in Posttraumatic Stress Disorder (PTSD) remains largely unexplored. This study aimed to determine whether symptoms improvement is associated with grey matter (GM) density changes of brain structures involved in PTSD. Two groups of PTSD patients were involved in this study. The first group was treated with Eye Movement Desensitization and Reprocessing (EMDR) therapy and recovered from their symptoms (recovery group) (n = 11); Patients were scanned prior to therapy (T1), one week (T2) and five months after the end of therapy (T3). The second group included patients which followed a supportive therapy and remained symptomatic (wait-list group) (n = 7). They were scanned at three time-steps mimicking the same inter-scan intervals. Voxel-based morphometry (VBM) was used to characterize GM density evolution. GM density values showed a significant group-by-time interaction effect between T1 and T3 in prefrontal cortex areas. These interaction effects were driven by a GM density increase in the recovery group with respect to the wait-list group. Symptoms removal goes hand-in-hand with GM density enhancement of structures involved in emotional regulation.<br /> (Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Prefrontal Cortex diagnostic imaging
Young Adult
Eye Movement Desensitization Reprocessing methods
Outcome Assessment, Health Care
Prefrontal Cortex pathology
Stress Disorders, Post-Traumatic diagnostic imaging
Stress Disorders, Post-Traumatic pathology
Stress Disorders, Post-Traumatic physiopathology
Stress Disorders, Post-Traumatic therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7506
- Volume :
- 266
- Database :
- MEDLINE
- Journal :
- Psychiatry research. Neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 28667881
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2017.06.009