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SSRIs associated with decreased risk of hepatocellular carcinoma: A population-based case-control study.
- Source :
-
Psycho-oncology [Psychooncology] 2018 Jan; Vol. 27 (1), pp. 187-192. Date of Electronic Publication: 2017 Aug 08. - Publication Year :
- 2018
-
Abstract
- Background: Hepatocellular carcinoma (HCC) is the second leading cancer-related cause of mortality worldwide. Antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), are commonly used worldwide. Available evidence investigating the association between SSRIs use and HCC risk is limited.<br />Objective: The present study aimed to investigate if the effect of all kinds of SSRIs on HCC was the same or not using population-based study.<br />Methods: The nationwide population-based study herein using Taiwan's National Health Insurance Research Database included a total of 59 859 cases with HCC and 285 124 matched controls. Conditional logistic regression analyses were adjusted for confounding variables.<br />Results: All common kinds of SSRIs including fluoxetine, sertraline, paroxetine, citalopram, escitalopram, and fluvoxamine were associated with lower HCC risk, and the findings were dose-dependent (eg, fluoxetine: 1-28 DDD [defined daily dose]: adjusted odds ratio [aOR]: 0.81, 95% confidence interval [CI], 0.73-0.89; 29-365 DDD: aOR: 0.71, 95% CI, 0.64-0.79; and ≥366 DDD: aOR: 0.55, 95% CI, 0.45-0.67) (P for trend < .001).<br />Conclusions: All kinds of SSRIs were associated with decreased risk of HCC.<br /> (Copyright © 2017 John Wiley & Sons, Ltd.)
- Subjects :
- Adult
Antidepressive Agents administration & dosage
Carcinoma, Hepatocellular diagnosis
Carcinoma, Hepatocellular epidemiology
Case-Control Studies
Databases, Factual
Female
Humans
Liver Neoplasms diagnosis
Liver Neoplasms epidemiology
Male
Middle Aged
Odds Ratio
Selective Serotonin Reuptake Inhibitors administration & dosage
Taiwan epidemiology
Antidepressive Agents adverse effects
Carcinoma, Hepatocellular chemically induced
Liver Neoplasms chemically induced
Selective Serotonin Reuptake Inhibitors adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1611
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Psycho-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28666060
- Full Text :
- https://doi.org/10.1002/pon.4493