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The Impact of Liver Graft Injury on Cancer Recurrence Posttransplantation.
- Source :
-
Transplantation [Transplantation] 2017 Nov; Vol. 101 (11), pp. 2665-2670. - Publication Year :
- 2017
-
Abstract
- Liver transplantation is the most effective treatment for selected patients with hepatocellular carcinoma. However, cancer recurrence, posttransplantation, remains to be the critical issue that affects the long-term outcome of hepatocellular carcinoma recipients. In addition to tumor biology itself, increasing evidence demonstrates that acute-phase liver graft injury is a result of hepatic ischemia reperfusion injury (which is an inevitable consequence during liver transplantation) and may promote cancer recurrence at late phase posttransplantation. The liver grafts from living donors, donors after cardiac death, and steatotic donors have been considered as promising sources of organs for liver transplantation and are associated with high incidence of liver graft injury. The acute-phase liver graft injury will trigger a series of inflammatory cascades, which may not only activate the cell signaling pathways regulating the tumor cell invasion and migration but also mobilize the circulating progenitor and immune cells to facilitate tumor recurrence and metastasis. The injured liver graft may also provide the favorable microenvironment for tumor cell growth, migration, and invasion through the disturbance of microcirculatory barrier function, induction of hypoxia and angiogenesis. This review aims to summarize the latest findings about the role and mechanisms of liver graft injury resulted from hepatic ischemia reperfusion injury on tumor recurrence posttransplantation, both in clinical and animal cohorts.
- Subjects :
- Animals
Carcinoma, Hepatocellular metabolism
Carcinoma, Hepatocellular secondary
Disease Progression
Humans
Liver metabolism
Liver pathology
Liver Neoplasms metabolism
Liver Neoplasms pathology
Liver Transplantation methods
Living Donors
Reperfusion Injury diagnosis
Reperfusion Injury metabolism
Reperfusion Injury pathology
Risk Factors
Signal Transduction
Time Factors
Treatment Outcome
Tumor Microenvironment
Carcinoma, Hepatocellular surgery
Liver surgery
Liver Neoplasms surgery
Liver Transplantation adverse effects
Neoplasm Recurrence, Local
Reperfusion Injury etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1534-6080
- Volume :
- 101
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 28665890
- Full Text :
- https://doi.org/10.1097/TP.0000000000001844