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Population pharmacokinetics of human antithrombin concentrate in paediatric patients.

Population pharmacokinetics of human antithrombin concentrate in paediatric patients.

Authors :
Moffett BS
Diaz R
Galati M
Mahoney D
Teruya J
Yee DL
Source :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2017 Nov; Vol. 83 (11), pp. 2450-2457. Date of Electronic Publication: 2017 Aug 11.
Publication Year :
2017

Abstract

Aims: Antithrombin is increasingly used in paediatric patients, yet there are few age-specific pharmacokinetic data to guide dosing. We aimed to describe the pharmacokinetic profile of human (plasma-derived) antithrombin concentrate in paediatric patients.<br />Methods: A 5-year retrospective review was performed of patients <19 years of age admitted to our institution who received antithrombin concentrate, were not on mechanical circulatory support and had baseline (predose) and postdose plasma antithrombin activity levels available for analysis. Demographic and laboratory variables, antithrombin dosing information and data on the use of continuous infusion unfractionated heparin were collected. Population pharmacokinetic analysis was performed with bootstrap analysis. The model developed was tested against a validation dataset from a cohort of similar patients, and a predictive value was calculated.<br />Results: A total 184 patients met the study criteria {46.7% male, median age [years] 0.35 [interquartile range (IQR) 0.07-3.9]}. A median of two antithrombin doses (IQR 1-4) were given to patients (at a dose of 46.3 ± 13.6 units kg <superscript>-1</superscript> ), with median of three (IQR 2-7) postdose levels per patient. Continuous infusion unfractionated heparin was administered in 87.5% of patients, at a mean dose of 34.1 ± 22.7 units kg <superscript>-1</superscript> h <superscript>-1</superscript> . A one-compartment exponential error model best fit the data, and significant covariates included allometrically scaled weight on clearance and volume of distribution, unfractionated heparin dose on clearance, and baseline antithrombin activity level on volume of distribution. The model resulted in a median -1.75% prediction error (IQR -11.75% to 6.5%) when applied to the validation dataset (n = 30).<br />Conclusions: Antithrombin pharmacokinetics are significantly influenced by the concurrent use of unfractionated heparin and baseline antithrombin activity.<br /> (© 2017 The British Pharmacological Society.)

Details

Language :
English
ISSN :
1365-2125
Volume :
83
Issue :
11
Database :
MEDLINE
Journal :
British journal of clinical pharmacology
Publication Type :
Academic Journal
Accession number :
28664670
Full Text :
https://doi.org/10.1111/bcp.13359