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Carotid artery plaques - Are risk factors the same in men and women with familial hypercholesterolemia?

Authors :
Waluś-Miarka M
Czarnecka D
Kloch-Badełek M
Wojciechowska W
Kapusta M
Malecki MT
Source :
International journal of cardiology [Int J Cardiol] 2017 Oct 01; Vol. 244, pp. 290-295. Date of Electronic Publication: 2017 Jun 21.
Publication Year :
2017

Abstract

Background and Aims: High low-density lipoprotein (LDL)-cholesterol levels are a major cause of premature coronary heart disease (CHD) and death in patients with familial hypercholesterolemia (FH). It is uncertain whether these risk factors affect men and women equally. We aimed to compare the risk factors of carotid plaques, which are reliable surrogates of coronary atherosclerosis, in men and women with FH.<br />Methods: 154 patients with FH (40.9% men) were included, diagnosed according to Simon Broome criteria. Carotid plaques were assessed by ultrasound.<br />Results: In women multiple logistic regression analysis revealed that systolic blood pressure, high-density lipoprotein-cholesterol (HDL-C), apolipoprotein (apo) A1, and alanine aminotransferase (ALT) were associated with the presence of carotid plaques. In this female cohort, the age adjusted odds ratio for the increase of HDL-C by 1 standard deviation was related to a 55% decrease in the odds of having carotid plaques (p=0.01) and the age adjusted odds ratio for the increase of ALT by 1U/L was related to a 7% in the increase odds of having carotid plaques (p=0.02). In men, in multiple logistic regression analysis only apo B concentration was significantly related to carotid plaque presence. The odds ratio for the increase of apo B by 1mg/dl corresponded to a 4% increase in the odds of having carotid plaques (p=0.01) and, interestingly, in men not treated with statin, this ratio reached 8% (p=0.04).<br />Conclusions: In summary, our study suggests a difference in risk factors of carotid artery plaques between men and women with FH.<br /> (Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1874-1754
Volume :
244
Database :
MEDLINE
Journal :
International journal of cardiology
Publication Type :
Academic Journal
Accession number :
28663044
Full Text :
https://doi.org/10.1016/j.ijcard.2017.06.076