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Carotid artery plaques - Are risk factors the same in men and women with familial hypercholesterolemia?
- Source :
-
International journal of cardiology [Int J Cardiol] 2017 Oct 01; Vol. 244, pp. 290-295. Date of Electronic Publication: 2017 Jun 21. - Publication Year :
- 2017
-
Abstract
- Background and Aims: High low-density lipoprotein (LDL)-cholesterol levels are a major cause of premature coronary heart disease (CHD) and death in patients with familial hypercholesterolemia (FH). It is uncertain whether these risk factors affect men and women equally. We aimed to compare the risk factors of carotid plaques, which are reliable surrogates of coronary atherosclerosis, in men and women with FH.<br />Methods: 154 patients with FH (40.9% men) were included, diagnosed according to Simon Broome criteria. Carotid plaques were assessed by ultrasound.<br />Results: In women multiple logistic regression analysis revealed that systolic blood pressure, high-density lipoprotein-cholesterol (HDL-C), apolipoprotein (apo) A1, and alanine aminotransferase (ALT) were associated with the presence of carotid plaques. In this female cohort, the age adjusted odds ratio for the increase of HDL-C by 1 standard deviation was related to a 55% decrease in the odds of having carotid plaques (p=0.01) and the age adjusted odds ratio for the increase of ALT by 1U/L was related to a 7% in the increase odds of having carotid plaques (p=0.02). In men, in multiple logistic regression analysis only apo B concentration was significantly related to carotid plaque presence. The odds ratio for the increase of apo B by 1mg/dl corresponded to a 4% increase in the odds of having carotid plaques (p=0.01) and, interestingly, in men not treated with statin, this ratio reached 8% (p=0.04).<br />Conclusions: In summary, our study suggests a difference in risk factors of carotid artery plaques between men and women with FH.<br /> (Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Apolipoprotein A-I blood
Carotid Stenosis epidemiology
Cholesterol, HDL blood
Female
Humans
Hyperlipoproteinemia Type II epidemiology
Male
Middle Aged
Risk Factors
Carotid Stenosis blood
Carotid Stenosis diagnostic imaging
Hyperlipoproteinemia Type II blood
Hyperlipoproteinemia Type II diagnostic imaging
Sex Characteristics
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 244
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 28663044
- Full Text :
- https://doi.org/10.1016/j.ijcard.2017.06.076