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Metabolic switching and cell fate decisions: implications for pluripotency, reprogramming and development.
- Source :
-
Current opinion in genetics & development [Curr Opin Genet Dev] 2017 Oct; Vol. 46, pp. 44-49. Date of Electronic Publication: 2017 Jul 04. - Publication Year :
- 2017
-
Abstract
- Cell fate decisions are closely linked to changes in metabolic activity. Over recent years this connection has been implicated in mechanisms underpinning embryonic development, reprogramming and disease pathogenesis. In addition to being important for supporting the energy demands of different cell types, metabolic switching from aerobic glycolysis to oxidative phosphorylation plays a critical role in controlling biosynthetic processes, intracellular redox state, epigenetic status and reactive oxygen species levels. These processes extend beyond ATP synthesis by impacting cell proliferation, differentiation, enzymatic activity, ageing and genomic integrity. This review will focus on how metabolic switching impacts decisions made by multipotent cells and discusses mechanisms by which this occurs.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0380
- Volume :
- 46
- Database :
- MEDLINE
- Journal :
- Current opinion in genetics & development
- Publication Type :
- Academic Journal
- Accession number :
- 28662447
- Full Text :
- https://doi.org/10.1016/j.gde.2017.06.008