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Dietary fructose causes defective insulin signalling and ceramide accumulation in the liver that can be reversed by gut microbiota modulation.
- Source :
-
Food & nutrition research [Food Nutr Res] 2017 Jun 09; Vol. 61 (1), pp. 1331657. Date of Electronic Publication: 2017 Jun 09 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Objective : The link between metabolic derangement of the gut-2013liver-visceral white adipose tissue (v-WAT) axis and gut microbiota was investigated. Methods : Rats were fed a fructose-rich diet and treated with an antibiotic mix. Inflammation was measured in portal plasma, ileum, liver, and v-WAT, while insulin signalling was analysed by measuring levels of phosphorylated kinase Akt. The function and oxidative status of hepatic mitochondria and caecal microbiota composition were also evaluated. Results : Ileal inflammation, increase in plasma transaminases, plasma peroxidised lipids, portal concentrations of tumour necrosis factor alpha, lipopolysaccharide, and non-esterified fatty acids, were induced by fructose and were reversed by antibiotic. The increased hepatic ceramide content, inflammation and decreased insulin signaling in liver and v-WAT induced by fructose was reversed by antibiotic. Antibiotic also blunted the increase in hepatic mitochondrial efficiency and oxidative damage of rats fed fructose-rich diet. Three genera, Coprococcus, Ruminococcus, and Clostridium, significantly increased, while the Clostridiaceae family significantly decreased in rats fed a fructose-rich diet, and antibiotic abolished these variations Conclusions : When gut microbiota modulation by fructose is prevented by antibiotic, inflammatory flow from the gut to the liver and v-WAT are reversed.
Details
- Language :
- English
- ISSN :
- 1654-661X
- Volume :
- 61
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Food & nutrition research
- Publication Type :
- Academic Journal
- Accession number :
- 28659742
- Full Text :
- https://doi.org/10.1080/16546628.2017.1331657