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Human adipose stem cells induced to osteogenic differentiation by an innovative collagen/hydroxylapatite hybrid scaffold.
Human adipose stem cells induced to osteogenic differentiation by an innovative collagen/hydroxylapatite hybrid scaffold.
- Source :
-
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2017 Oct; Vol. 31 (10), pp. 4555-4565. Date of Electronic Publication: 2017 Jun 28. - Publication Year :
- 2017
-
Abstract
- Novel biomaterials are of paramount importance for bone regrowth. In this study, we investigated human adipose stem cells (hASCs) for osteogenic, osteoconductivity, and osteoinductivity effects of an innovative collagen/hydroxylapatite hybrid scaffold. In hASCs that were grown on this scaffold, osteogenic genes were analyzed for their expression profiles, together with adhesion and extracellular matrix genes. In hASC integrins, basement membrane constituents and collagens were up-regulated, together with cell proliferation. In addition, expression of osteopontin and activated focal adhesion kinase was studied at the protein level. Our in vitro data indicate that hASCs, together with hybrid biomaterial, is an important model of study to investigate in vitro bone induction.-Mazzoni, E., D'Agostino, A., Manfrini, M., Maniero, S., Puozzo, A., Bassi, E., Marsico, S., Fortini, C., Trevisiol, L., Patergnani, S., Tognon, M. Human adipose stem cells induced to osteogenic differentiation by an innovative collagen/hydroxylapatite hybrid scaffold.<br /> (© FASEB.)
- Subjects :
- Adipocytes drug effects
Adipocytes metabolism
Adipose Tissue drug effects
Adipose Tissue metabolism
Biocompatible Materials pharmacology
Bone and Bones drug effects
Bone and Bones metabolism
Cell Proliferation drug effects
Cells, Cultured
Extracellular Matrix metabolism
Humans
Stem Cells drug effects
Tissue Scaffolds
Adipocytes cytology
Adipose Tissue cytology
Cell Differentiation drug effects
Collagen metabolism
Osteogenesis drug effects
Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6860
- Volume :
- 31
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 28659417
- Full Text :
- https://doi.org/10.1096/fj.201601384R