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Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression.
- Source :
-
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2018 Aug; Vol. 19 (5), pp. 402-409. Date of Electronic Publication: 2017 Jul 12. - Publication Year :
- 2018
-
Abstract
- Objectives: Current evidence supports participation of neurotrophic and inflammatory factors in the pathogenesis of major depressive disorder (MDD). Some studies reported an association between the Val66Met polymorphism (rs6265) of brain-derived neurotrophic factor (BDNF) gene with MDD and peripheral BDNF levels. However, no previous studies have examined the association of this polymorphism with inflammation. The present study assessed the association of the Val66Met polymorphism with serum levels of BDNF and inflammatory markers among depressed outpatients.<br />Methods: All participants (n = 73) met DSM-IV criteria for a unipolar depressive episode. The serum levels of BDNF and inflammatory biomarkers (IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ) were compared between individuals presenting with at least one Met allele (Met-carriers) and those homozygous for the Val allele.<br />Results: In our sample (84.9% female, mean age 52.4 ± 10.3 years), 24.7% (n = 18) were Met-carriers. After Bonferroni correction, the Met allele was significantly associated with higher BDNF and lower TNF-α. These associations persisted after adjusting for potential confounders.<br />Conclusions: The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism. The association of a polymorphism in the BDNF gene with inflammatory markers in addition to BDNF levels suggests an interaction between these systems.
- Subjects :
- Adult
Biomarkers blood
Female
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Brain-Derived Neurotrophic Factor blood
Brain-Derived Neurotrophic Factor genetics
Depressive Disorder, Major blood
Depressive Disorder, Major genetics
Depressive Disorder, Major immunology
Inflammation blood
Tumor Necrosis Factor-alpha blood
Subjects
Details
- Language :
- English
- ISSN :
- 1814-1412
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 28656803
- Full Text :
- https://doi.org/10.1080/15622975.2017.1347713