Viscoelastic power law parameters of in vivo human brain estimated by MR elastography.

Authors :: Testu J
McGarry MDJ
Dittmann F
Weaver JB
Paulsen KD
Sack I
Van Houten EEW
Source :: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2017 Oct; Vol. 74, pp. 333-341. Date of Electronic Publication: 2017 Jun 21.
Publication Year :: 2017
Abstract: The noninvasive imaging technique of magnetic resonance elastography (MRE) was used to estimate the power law behavior of the viscoelastic properties of the human brain in vivo. The mechanical properties for four volunteers are investigated using shear waves induced over a frequency range of 10-50Hz to produce a displacement field measured by magnetic resonance motion-encoding gradients. The average storage modulus (μ <subscript>R</subscript> ) reconstructed with non-linear inversion (NLI) increased from approximately 0.95 to 2.58kPa over the 10-50Hz span; the average loss modulus (μ <subscript>I</subscript> ) also increased from 0.29 to 1.25kPa over the range. These increases were modeled by independent power law (PL) relations for μ <subscript>R</subscript> and μ <subscript>I</subscript> returning whole brain, group mean exponent values of 0.88 and 1.07 respectively. Investigation of these exponents also showed distinctly different behavior in the region of the cerebral falx compared to other brain structures.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Subjects :: Adult
Elastic Modulus
Female
Humans
Male
Middle Aged
Motion
Brain physiology
Elasticity Imaging Techniques

Full Text Access

Tools