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Imaging of Myocardial Ischemia-Reperfusion Injury Using Sodium [ 18 F]Fluoride Positron Emission Tomography/Computed Tomography in Rats and Humans.
- Source :
-
Molecular imaging [Mol Imaging] 2017 Jan 01; Vol. 16, pp. 1536012117704767. - Publication Year :
- 2017
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Abstract
- Positron emission tomography (PET)/computed tomography (CT) using sodium [ <superscript>18</superscript> F]fluoride (Na[ <superscript>18</superscript> F]F) has been proven to be a promising hot-spot imaging modality for myocardial infarction (MI). We investigated Na[ <superscript>18</superscript> F]F uptake in ischemia-reperfusion injury (IRI) of rats and humans. Sodium [ <superscript>18</superscript> F]fluoride PET/CT was performed in Sprague-Dawley rats that had IRI surgery, and it readily demonstrated prominent Na[ <superscript>18</superscript> F]F uptake in the infarct area post-IRI. Sodium [ <superscript>18</superscript> F]fluoride uptake was matched with negative 2,3,5-triphenyl-2 H-tetrazolium chloride staining results, accompanied by myocardial apoptosis and associated with positive calcium staining results. Furthermore, area at risk was negative for Na[ <superscript>18</superscript> F]F uptake. Cyclosporine A (CysA) treatment reduced standardized uptake value of <superscript>18</superscript> F over the infarct area, and a significant decrease in infarct size was also observed by the CysA treatment. In humans, Na[ <superscript>18</superscript> F]F PET/CT readily demonstrated increased Na[ <superscript>18</superscript> F]F uptake in the 2 patients with MI post-percutaneous coronary intervention. In conclusion, this study sheds light on the potential utility of Na[ <superscript>18</superscript> F]F PET/CT as a hot-spot imaging modality for myocardial IRI.
Details
- Language :
- English
- ISSN :
- 1536-0121
- Volume :
- 16
- Database :
- MEDLINE
- Journal :
- Molecular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 28654382
- Full Text :
- https://doi.org/10.1177/1536012117704767