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Cyclized 9,11-secosterol enol-ethers from the gorgonian Pseudopterogorgia americana.
- Source :
-
Steroids [Steroids] 2017 Sep; Vol. 125, pp. 47-53. Date of Electronic Publication: 2017 Jun 23. - Publication Year :
- 2017
-
Abstract
- Chemical investigation of the MeOH extract from the gorgonian Pseudopterogorgia americana afforded two rare sterols, ameristerenol A (1) and B (2), both 9,11-secosterols possesses a seven-membered cyclic enol-ether in ring C, and ameristerol A (3) is the first example of a naturally occurring 9,11-secosterol containing a gorgosterol side chain with a C-24(28) double bond. Ameristerenol A (1) was converted to the sterol derivatives 4-6 to provide additional chemical diversity and comparison for biological screening. The structures of compounds 1-6, along with three related known analogues 7-9, were determined on the basis of extensive spectroscopic analysis and by comparison with literature data. Compound 6 exhibited slight cytotoxicity activity against human breast cancer cell line MDA-MB-231.<br /> (Copyright © 2017. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1878-5867
- Volume :
- 125
- Database :
- MEDLINE
- Journal :
- Steroids
- Publication Type :
- Academic Journal
- Accession number :
- 28648587
- Full Text :
- https://doi.org/10.1016/j.steroids.2017.06.008