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Acute monocytic leukemia in an irradiated Beagle.
- Source :
-
Veterinary pathology [Vet Pathol] 1979 Mar; Vol. 16 (2), pp. 243-54. - Publication Year :
- 1979
-
Abstract
- A purebred female Beagle dog that had received 2,000 R of protracted wholebody gamma-irradiation from 60Co when 14 months old had hematologic changes consistent with a myeloproliferative disorder 3 years after the termination of radiation exposure. Peripheral blood and bone marrow findings during the 7-month period before death showed progressive anemia with increased numbers of platelets; immature granulocytes, monocytes and promonocytes. A period of partial remission occurred during which time the peripheral blood was aleukemic, although there was marked thrombocytosis and abnormal erythropoiesis which was evidenced by bizarre circulating nucleated red cells, anisocytosis, poikilocytosis and Howell-Jolly bodies. The dog had a terminal crisis with marked leukocytosis, most cells in the peripheral blood being bizarre monocytes and promonocytes. Tissues obtained at necropsy showed diffuse as well as focal infiltration of the spleen, liver, lymph nodes, heart, kidney and gastrointestinal wall with immature neoplastic cells resembling monocytes and monocytic precursors. The monocytic differentiation of the invasive cell population was confirmed by morphological, cytochemical, histological, ultrastructural and in vitro cell culture studies.
- Subjects :
- Animals
Blood Cells ultrastructure
Dog Diseases blood
Dogs
Female
Leukemia, Experimental blood
Leukemia, Experimental pathology
Leukemia, Monocytic, Acute blood
Leukemia, Monocytic, Acute pathology
Leukemia, Radiation-Induced blood
Leukemia, Radiation-Induced pathology
Dog Diseases pathology
Leukemia, Experimental veterinary
Leukemia, Monocytic, Acute veterinary
Leukemia, Radiation-Induced veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0300-9858
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Veterinary pathology
- Publication Type :
- Academic Journal
- Accession number :
- 286469
- Full Text :
- https://doi.org/10.1177/030098587901600210