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A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics.
- Source :
-
Scientific reports [Sci Rep] 2017 Jun 23; Vol. 7 (1), pp. 4131. Date of Electronic Publication: 2017 Jun 23. - Publication Year :
- 2017
-
Abstract
- In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped fluorescent mesoporous silica nanoparticles (MSNs), long rod nanoparticles (NLR), short rod nanoparticles (NSR), and spherical nanoparticles (NS) to systematically examine their behavior in vivo after oral administration. The results of the ex vivo optical imaging study in mice indicated that rod nanoparticles had a longer residence time in the gastrointestinal compared with spherical nanoparticles. The in vivo biodistribution showed that all the orally administered MSNs were mainly taken up by the liver, and kidney. NLR had a great capacity to overcoming rapid clearance by the RES and exhibited a longer circulation in the blood than NSR and NS. During renal excretion, the spherical nanoparticles were cleared faster than rod nanoparticles. In addition, it was also found that MSNs can be degraded in vivo and NSR were degraded faster than NLR and NS probably owing to their higher specific surface area. The pharmacokinetic results demonstrated that nifedipine(NI)-loaded NLR had a higher bioavailability than NI-loaded NSR and NS.
- Subjects :
- Animals
Biological Availability
Carboxylic Acids chemistry
Cell Line
Drug Delivery Systems
Gastric Mucosa metabolism
Gastric Mucosa pathology
Male
Mice
Nanoparticles chemistry
Nanoparticles ultrastructure
Rats
Silicon Dioxide chemistry
Tissue Distribution
Nanoparticles administration & dosage
Nanoparticles metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28646143
- Full Text :
- https://doi.org/10.1038/s41598-017-03834-2