Epigenome dysregulation in cholangiocarcinoma.

Authors :: O'Rourke CJ
Munoz-Garrido P
Aguayo EL
Andersen JB
Source :: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2018 Apr; Vol. 1864 (4 Pt B), pp. 1423-1434. Date of Electronic Publication: 2017 Jun 20.
Publication Year :: 2018
Abstract: Epigenomics is a fast-evolving field of research that has lately attracted considerable interest, mainly due to the reversibility of epigenetic marks. Clinically, among solid tumors, the field is still limited. In cholangiocarcinoma (CCA) it is well known that the epigenetic landscape is deregulated both during carcinogenesis and disease progression as a consequence of aberrant mechanisms leading to genome instability. In this article, we will briefly review the molecular alterations that have been described in the transformation of normal cholangiocytes into malignant derivatives, focusing on the role of non-coding RNA (ncRNA) interactions, DNA methylation, post-translational modifications (PTMs) of histones and chromatin remodeling complexes.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)