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A case report of septic shock syndrome caused by S. pneumoniae in an immunocompromised patient despite of vaccination.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2017 Jun 22; Vol. 17 (1), pp. 442. Date of Electronic Publication: 2017 Jun 22. - Publication Year :
- 2017
-
Abstract
- Background and Case Presentation: We report a case of septic shock syndrome caused by Streptococcus pneumoniae in a patient who had undergone splenectomy due to an autoimmune lymphoproliferative syndrome (ALPS), which is characterized as a dysfunction of immunoregulation. Although the patient was vaccinated with a conjugated polysaccharide vaccine after the splenectomy, he was still susceptible to S. pneumoniae infection, because the isolated serovar (24F), a serovar long thought to be apathogenic, is not covered by any vaccine currently approved, neither a conjugated nor an unconjugated polysaccharide one.<br />Conclusions: This case demonstrates that, due to presence of different serovars, also infections with bacteria against which patients are vaccinated have to be considered as differential diagnosis. Although vaccine development has extended the coverage of S. pneumoniae from 7 to 23 serovars within recent years, there is still demand for novel vaccines which can provide broader protection also against so-thought "apathogenic" strains, especially for groups at high risk.
- Subjects :
- Adult
Autoimmune Lymphoproliferative Syndrome surgery
Humans
Immunocompromised Host
Male
Pneumococcal Infections microbiology
Pneumococcal Infections prevention & control
Serogroup
Shock, Septic drug therapy
Splenectomy
Streptococcus pneumoniae immunology
Streptococcus pneumoniae isolation & purification
Streptococcus pneumoniae pathogenicity
Treatment Failure
Vaccines, Conjugate pharmacology
Pneumococcal Infections complications
Pneumococcal Vaccines pharmacology
Shock, Septic microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 28641577
- Full Text :
- https://doi.org/10.1186/s12879-017-2481-y