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The Role of Hemoproteins: Hemoglobin, Myoglobin and Neuroglobin in Endogenous Thiosulfate Production Processes.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2017 Jun 20; Vol. 18 (6). Date of Electronic Publication: 2017 Jun 20. - Publication Year :
- 2017
-
Abstract
- Thiosulfate formation and biodegradation processes link aerobic and anaerobic metabolism of cysteine. In these reactions, sulfite formed from thiosulfate is oxidized to sulfate while hydrogen sulfide is transformed into thiosulfate. These processes occurring mostly in mitochondria are described as a canonical hydrogen sulfide oxidation pathway. In this review, we discuss the current state of knowledge on the interactions between hydrogen sulfide and hemoglobin, myoglobin and neuroglobin and postulate that thiosulfate is a metabolically important product of this processes. Hydrogen sulfide oxidation by ferric hemoglobin, myoglobin and neuroglobin has been defined as a non-canonical hydrogen sulfide oxidation pathway. Until recently, it appeared that the goal of thiosulfate production was to delay irreversible oxidation of hydrogen sulfide to sulfate excreted in urine; while thiosulfate itself was only an intermediate, transient metabolite on the hydrogen sulfide oxidation pathway. In the light of data presented in this paper, it seems that thiosulfate is a molecule that plays a prominent role in the human body. Thus, we hope that all these findings will encourage further studies on the role of hemoproteins in the formation of this undoubtedly fascinating molecule and on the mechanisms responsible for its biological activity in the human body.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Cysteine metabolism
Hemeproteins physiology
Humans
Hydrogen Sulfide metabolism
Mitochondria metabolism
Neuroglobin
Oxidation-Reduction
Sulfides metabolism
Sulfites metabolism
Globins physiology
Hemoglobins physiology
Myoglobin physiology
Nerve Tissue Proteins physiology
Thiosulfates metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28632164
- Full Text :
- https://doi.org/10.3390/ijms18061315