Back to Search
Start Over
Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes.
- Source :
-
Scientific reports [Sci Rep] 2017 Jun 19; Vol. 7 (1), pp. 3802. Date of Electronic Publication: 2017 Jun 19. - Publication Year :
- 2017
-
Abstract
- Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopausal females with type 2 diabetes. The overall prevalence of SRC was 18.1% in our population. SRC prevalence was significantly higher in hyperuricemic than normouricemic subjects (27.3% vs. 16.8%, P < 0.001). Subjects who overexcreted uric acid had a higher prevalence of SRC than underexcretors (total population: 21.6% vs. 16.3%; normouricemic subjects: 19.8% vs. 13.7%; hyperuricemic subjects: 50.0% vs. 22.7%, all P-values < 0.05). Hyperuricemia (odds ratio [OR] 1.824, 95% confidence interval [CI] 1.332-2.498, P < 0.001); FEUA (OR 1.046, 95% CI 1.002-1.091, P < 0.05); male gender (OR 1.922, 95% CI 1.489-2.480, P < 0.001); age (OR 1.049, 95% CI 1.035-1.064, P < 0.001); and albuminuria (OR 1.492, 95% CI 1.176-1.892, P < 0.01) were independent risk factors for SRC development. These findings suggested that hyperuricemia and high level of FEUA were both independent risk factors for SRC development in males and postmenopausal females with type 2 diabetes. Half of overproduction hyperuricemic patients had SRC.
- Subjects :
- Aged
Cysts pathology
Diabetes Mellitus, Type 2 epidemiology
Diabetes Mellitus, Type 2 pathology
Diabetic Nephropathies epidemiology
Diabetic Nephropathies pathology
Female
Humans
Hyperuricemia epidemiology
Kidney pathology
Male
Middle Aged
Prevalence
Risk Factors
Sex Characteristics
Cysts urine
Diabetes Mellitus, Type 2 urine
Diabetic Nephropathies urine
Hyperuricemia urine
Kidney metabolism
Uric Acid urine
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28630500
- Full Text :
- https://doi.org/10.1038/s41598-017-04036-6