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EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2017 Jun 18; Vol. 18 (6). Date of Electronic Publication: 2017 Jun 18. - Publication Year :
- 2017
-
Abstract
- Epidermal growth factor receptor (EGFR) and the mutant EGFRvIII are major focal points in current concepts of targeted cancer therapy for glioblastoma multiforme (GBM), the most malignant primary brain tumor. The receptors participate in the key processes of tumor cell invasion and tumor-related angiogenesis and their upregulation correlates with the poor prognosis of glioma patients. Glioma cell invasion and increased angiogenesis share mechanisms of the degradation of the extracellular matrix (ECM) through upregulation of ECM-degrading proteases as well as the activation of aberrant signaling pathways. This review describes the role of EGFR and EGFRvIII in those mechanisms which might offer new combined therapeutic approaches targeting EGFR or EGFRvIII together with drug treatments against proteases of the ECM or downstream signaling to increase the inhibitory effects of mono-therapies.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Animals
Brain Neoplasms metabolism
Combined Modality Therapy
Glioblastoma metabolism
Humans
Molecular Targeted Therapy
Neovascularization, Pathologic metabolism
Neovascularization, Pathologic pathology
Brain Neoplasms blood supply
Brain Neoplasms therapy
ErbB Receptors metabolism
Glioblastoma blood supply
Glioblastoma therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28629170
- Full Text :
- https://doi.org/10.3390/ijms18061295