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High titer of anti-citrullinated peptide antibody is a risk factor for severe carotid atherosclerotic plaque in patients with rheumatoid arthritis: the TOMORROW study.
- Source :
-
International journal of rheumatic diseases [Int J Rheum Dis] 2017 Aug; Vol. 20 (8), pp. 949-959. Date of Electronic Publication: 2017 Jun 19. - Publication Year :
- 2017
-
Abstract
- Aim: Cardiovascular disease is one of the complications of rheumatoid arthritis (RA). We researched the morbidity and severity of existing carotid atherosclerosis plaque and associated risk factors in patients with RA.<br />Method: This study included 413 participants, including 208 patients with RA and 205 age- and sex-matched healthy volunteers. Carotid ultrasound, clinical data collection and assessment of cardiovascular risk factors were performed. Atherosclerotic plaque was defined as an intima-media thickness ≥ 1.1 mm. Severity of plaque was assessed by plaque score, defined as the sum of the maximal thickness of all plaques in bilateral carotid arteries.<br />Results: Data were analyzed from 200 patients with RA and 202 controls. Carotid plaque was observed more frequently in patients with RA than controls (47.0 vs. 36.1%, P = 0.027). Moreover, plaque score was significantly higher in RA patients (P = 0.032). In logistic regression analysis, RA represented an independent risk factor for the presence of plaque (adjusted odds ratio, 1.68; 95% confidence interval, 1.03-2.74). Comparing RA patients with and without plaque, anti-cyclic citrullinated peptide (anti-CCP) antibodies titer was significantly higher in patients with plaque (315.8 ± 454.1 U/mL) than in patients without (165.7 ± 281.1 U/mL; P = 0.005). Moreover, multiple linear regression analysis clarified that anti-CCP antibody titer was associated with plaque score in patients with RA.<br />Conclusion: High prevalence of any carotid plaques and severe carotid plaques were more frequent in patients with RA. High titer of anti-CCP antibodies represented a risk factor for severe carotid atherosclerotic plaque in patients with RA.<br /> (© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid diagnosis
Arthritis, Rheumatoid epidemiology
Arthritis, Rheumatoid immunology
Biomarkers blood
Carotid Arteries diagnostic imaging
Carotid Artery Diseases diagnostic imaging
Carotid Artery Diseases epidemiology
Carotid Intima-Media Thickness
Case-Control Studies
Chi-Square Distribution
Cross-Sectional Studies
Female
Humans
Japan epidemiology
Linear Models
Logistic Models
Male
Middle Aged
Odds Ratio
Prevalence
Prospective Studies
Risk Factors
Severity of Illness Index
Young Adult
Anti-Citrullinated Protein Antibodies blood
Arthritis, Rheumatoid blood
Carotid Arteries pathology
Carotid Artery Diseases pathology
Plaque, Atherosclerotic
Subjects
Details
- Language :
- English
- ISSN :
- 1756-185X
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of rheumatic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 28627096
- Full Text :
- https://doi.org/10.1111/1756-185X.13106