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Long non-coding RNA UCA1 promotes gallbladder cancer progression by epigenetically repressing p21 and E-cadherin expression.
- Source :
-
Oncotarget [Oncotarget] 2017 Jul 18; Vol. 8 (29), pp. 47957-47968. - Publication Year :
- 2017
-
Abstract
- A growing number of studies indicated that long non-coding RNAs (lncRNAs) determine some cellular processes in cancer, such as proliferation, metastasis and differentiation. Urothelial carcinoma associated 1 (UCA1), an lncRNA, had been reported for its overexpression and oncogenic effect on various human cancers. In this study, we found that UCA1 was significantly overexpressed in gallbladder cancer (GBC) and positively correlated with tumor size, lymph node metastasis, TNM stage and short survival time. Moreover, UCA1 promoted GBC cell proliferation and metastasis in vitro and tumor growth in vivo. Mechanically, we identified that UCA1 promoted GBC progression through recruiting enhancer of zeste homolog 2 (EZH2) to the promoter of p21 and E-cadherin, and epigenetically suppressing their transcript.
- Subjects :
- Adult
Aged
Animals
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic
Disease Models, Animal
Disease Progression
Enhancer of Zeste Homolog 2 Protein metabolism
Epithelial-Mesenchymal Transition
Female
Gallbladder Neoplasms mortality
Heterografts
Humans
Lymphatic Metastasis
Male
Mice
Middle Aged
Neoplasm Grading
Neoplasm Staging
Prognosis
Promoter Regions, Genetic
Protein Binding
Transcription, Genetic
Tumor Burden
Cadherins genetics
Cyclin-Dependent Kinase Inhibitor p21 genetics
Epigenesis, Genetic
Gallbladder Neoplasms genetics
Gallbladder Neoplasms pathology
Gene Expression Regulation, Neoplastic
RNA, Long Noncoding genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 8
- Issue :
- 29
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 28624787
- Full Text :
- https://doi.org/10.18632/oncotarget.18204