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BAG3 promotes proliferation of ovarian cancer cells via post-transcriptional regulation of Skp2 expression.
- Source :
-
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2017 Oct; Vol. 1864 (10), pp. 1668-1678. Date of Electronic Publication: 2017 Jun 15. - Publication Year :
- 2017
-
Abstract
- Bcl-2 associated athanogene 3 (BAG3) contains a modular structure, through which BAG3 interacts with a wide range of proteins, thereby affording its capacity to regulate multifaceted biological processes. BAG3 is often highly expressed and functions as a pro-survival factor in many cancers. However, the oncogenic potential of BAG3 remains not fully understood. The cell cycle regulator, S-phase kinase associated protein 2 (Skp2) is increased in various cancers and plays an important role in tumorigenesis. The current study demonstrated that BAG3 promoted proliferation of ovarian cancer cells via upregulation of Skp2. BAG3 stabilized Skp2 mRNA via its 3'-untranslated region (UTR). The current study demonstrated that BAG3 interacted with Skp2 mRNA. In addition, miR-21-5p suppressed Skp2 expression, which was compromised by forced BAG3 expression. These results indicated that at least some oncogenic functions of BAG3 were mediated through posttranscriptional regulation of Skp2 via antagonizing suppressive action of miR-21-5p in ovarian cancer cells.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Cell Line, Tumor
Cell Proliferation genetics
Female
Gene Expression Regulation, Neoplastic
Humans
Mice
Ovarian Neoplasms pathology
RNA Processing, Post-Transcriptional genetics
RNA, Messenger genetics
Xenograft Model Antitumor Assays
Adaptor Proteins, Signal Transducing genetics
Apoptosis Regulatory Proteins genetics
MicroRNAs genetics
Ovarian Neoplasms genetics
S-Phase Kinase-Associated Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0167-4889
- Volume :
- 1864
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta. Molecular cell research
- Publication Type :
- Academic Journal
- Accession number :
- 28624440
- Full Text :
- https://doi.org/10.1016/j.bbamcr.2017.06.004