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Elevated serum fibroblast growth factor 23 levels as an indicator of lower extremity atherosclerotic disease in Chinese patients with type 2 diabetes mellitus.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2017 Jun 15; Vol. 16 (1), pp. 77. Date of Electronic Publication: 2017 Jun 15. - Publication Year :
- 2017
-
Abstract
- Background: Recently, basic and clinical studies have provided evidence supporting the relationship between circulating levels of fibroblast growth factor (FGF) 23 and the development of atherosclerosis. Given that diabetes is an established risk factor for lower extremity atherosclerotic disease (LEAD), the goal of the present study was to explore the relationship between serum FGF23 levels and LEAD, as well as the related factors, in Chinese patients with type 2 diabetes mellitus (T2DM).<br />Methods: A total of 401 hospitalized T2DM patients (201 subjects with LEAD and 200 subjects without LEAD) were enrolled in this study. Serum FGF23 levels were determined by a sandwich enzyme-linked immunosorbent assay. Femoral intima-media thickness (F-IMT) and lower limb atherosclerotic plaque were assessed through color Doppler ultrasound.<br />Results: The median (interquartile range) serum FGF23 levels in the entire study population was 42.08 (35.59-49.17) pg/mL. Subjects with LEAD had significantly higher serum FGF23 levels compared with those without LEAD (44.00 [37.54-51.30] pg/mL versus 40.42 [32.61-48.23] pg/mL, P < 0.001). Logistic regression showed that serum FGF23 levels were independently and positively correlated with the presence of LEAD (odds ratio 1.039, 95% confidence interval 1.012-1.067, P = 0.004). In addition, multiple liner regression analysis revealed that serum FGF23 levels were positively associated with F-IMT (standardized β = 0.175, P < 0.001). Furthermore, this relationship remained significant after additional adjustment for gender and factors potentially affecting serum FGF23 levels (serum calcium, serum phosphorus, and glomerular filtration rate), respectively (both P < 0.01).<br />Conclusions: In Chinese patients with T2DM, serum FGF23 levels were independently and positively correlated with the presence of LEAD.
- Subjects :
- Adult
Aged
Asian People
Biomarkers blood
Case-Control Studies
Chi-Square Distribution
China
Cross-Sectional Studies
Diabetes Mellitus, Type 2 diagnosis
Diabetes Mellitus, Type 2 ethnology
Enzyme-Linked Immunosorbent Assay
Female
Fibroblast Growth Factor-23
Hospitalization
Humans
Linear Models
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Peripheral Arterial Disease diagnostic imaging
Peripheral Arterial Disease ethnology
Plaque, Atherosclerotic
Predictive Value of Tests
Prognosis
Risk Factors
Ultrasonography, Doppler, Color
Up-Regulation
Diabetes Mellitus, Type 2 blood
Fibroblast Growth Factors blood
Lower Extremity blood supply
Peripheral Arterial Disease blood
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 28619026
- Full Text :
- https://doi.org/10.1186/s12933-017-0559-x