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The efficacy and safety of bimatoprost/timolol maleate, latanoprost/timolol maleate, and travoprost/timolol maleate fixed combinations on 24-h IOP.
- Source :
-
International ophthalmology [Int Ophthalmol] 2018 Aug; Vol. 38 (4), pp. 1425-1431. Date of Electronic Publication: 2017 Jun 14. - Publication Year :
- 2018
-
Abstract
- Purpose: To evaluate the effect of bimatoprost/timolol maleate fixed combination (BTFC), latanoprost/timolol maleate fixed combination (LTFC), and travoprost/timolol maleate fixed combination (TTFC) on 24-h intraocular pressure (IOP) in patients with open-angle glaucoma.<br />Methods: This prospective, observer-masked, randomized study included 50 patients with primary open-angle glaucoma. All patients were using hypotensive lipids and timolol maleate fixed combination treatment for ≥4 weeks and had an IOP ≤ 21 mmHg. Group 1 (n = 18) received BTFC, group 2 (n = 14) received LTFC, and group 3 (n = 18) received TTFC. All patients were hospitalized, and IOP was monitored for 24-h (10:00, 14:00, 18:00, 22:00, 02:00, and 06:00). Mean diurnal IOP variation measurements were taken between 06:00 and 18:00, and mean nocturnal IOP variation measurements were taken between 22:00 and 02:00. Mean IOP and IOP variation in the three groups were compared.<br />Results: Mean 24-h IOP did not differ significantly between the three groups (group 1: 14.6 ± 2.9 mmHg; group 2: 14.1 ± 3.7 mmHg and group 3: 15.8 ± 2.0 mmHg; P > 0.05). Mean diurnal IOP variation was 4.6 ± 2.3 mmHg in group 1, 5.8 ± 2.4 mmHg in group 2, and 4.3 ± 1.7 mmHg in group 3, and mean nocturnal IOP variation was 3.2 ± 2.8 mmHg in group 1, 2.9 ± 1.9 mmHg in group 2, and 3.0 ± 1.6 mmHg group 3. There were not any significant differences in diurnal or nocturnal IOP variation between the three groups (P < 0.05).<br />Conclusion: All three fixed combinations effectively controlled IOP for 24-h and had a similar effect on diurnal and nocturnal IOP variations.
- Subjects :
- Aged
Aged, 80 and over
Dose-Response Relationship, Drug
Drug Substitution
Drug Therapy, Combination
Female
Follow-Up Studies
Glaucoma, Open-Angle diagnosis
Glaucoma, Open-Angle physiopathology
Gonioscopy
Humans
Intraocular Pressure drug effects
Latanoprost
Male
Middle Aged
Monitoring, Physiologic
Prospective Studies
Single-Blind Method
Tonometry, Ocular
Treatment Outcome
Bimatoprost administration & dosage
Circadian Rhythm
Glaucoma, Open-Angle drug therapy
Intraocular Pressure physiology
Prostaglandins F, Synthetic administration & dosage
Timolol administration & dosage
Travoprost administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2630
- Volume :
- 38
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 28616797
- Full Text :
- https://doi.org/10.1007/s10792-017-0601-8