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Effect of the parasympathetic system on secretion of parathyroid hormone.
- Source :
-
Metabolism: clinical and experimental [Metabolism] 1985 Jul; Vol. 34 (7), pp. 612-5. - Publication Year :
- 1985
-
Abstract
- This study evaluated the effect of parasympathetic agonists and antagonists on immunoreactive (i) PTH secretion in vitro and on serum iPTH in vivo in rats. In in vitro studies pilocarpine or bethanechol significantly inhibited PTH secretion. This inhibition was blocked by the simultaneous addition of atropine to the incubation medium. In in vivo studies, the cholinergic agonists pilocarpine and bethanechol and the cholinergic antagonist atropine were administered to rats by IV infusion. Blood was obtained before and again after two hours of infusion for analysis of iPTH. Pilocarpine or bethanechol significantly decreased serum iPTH. This inhibition by either agent was blocked by the simultaneous administration of atropine. Administration of atropine alone significantly increased serum iPTH above baseline. This stimulation of basal serum iPTH by parasympathetic blockade suggests that even basal PTH secretion may be influenced by endogenous parasympathetic tone. Therefore, the following conclusions were reached: (1) parasympathetic influences inhibit PTH secretion, and (2) endogenous parasympathetic tone may be an inhibitory modulator of basal secretion of PTH.
- Subjects :
- Animals
Atropine pharmacology
Bethanechol
Bethanechol Compounds pharmacology
Calcium metabolism
Culture Media analysis
In Vitro Techniques
Parasympathetic Nervous System drug effects
Parathyroid Hormone blood
Pilocarpine pharmacology
Radioimmunoassay
Rats
Rats, Inbred Strains
Parasympathetic Nervous System metabolism
Parathyroid Glands metabolism
Parathyroid Hormone metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0026-0495
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Metabolism: clinical and experimental
- Publication Type :
- Academic Journal
- Accession number :
- 2861555
- Full Text :
- https://doi.org/10.1016/0026-0495(85)90086-1