Back to Search Start Over

[The biological complexity of Polycomb group proteins: the case of EZH2].

Authors :
Koubi M
Chabannon C
Duprez E
Source :
Medecine sciences : M/S [Med Sci (Paris)] 2017 May; Vol. 33 (5), pp. 499-505. Date of Electronic Publication: 2017 Jun 14.
Publication Year :
2017

Abstract

Polycomb Group proteins (PcG) are repressive epigenetic factors essential for development and involved in numerous cancer processes, yet their modes of action and recruitment to specific genomic loci are not fully understood. Recently, it has been shown that the PcG protein recruitment is a dynamic process, contrary to what was foreseen in the initial hierarchical model. In addition, EZH2, a key PcG protein, can be associated to transcribed genes, challenging the former function of PcG proteins as transcriptional repressors. Furthermore, the dual role of EZH2, which can act as an oncogene or a tumor suppressor depending on the cellular type, illustrates the functional complexity of PcG proteins.<br /> (© 2017 médecine/sciences – Inserm.)

Details

Language :
French
ISSN :
1958-5381
Volume :
33
Issue :
5
Database :
MEDLINE
Journal :
Medecine sciences : M/S
Publication Type :
Academic Journal
Accession number :
28612725
Full Text :
https://doi.org/10.1051/medsci/20173305013