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Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.

Authors :
Kerr KF
Avery CL
Lin HJ
Raffield LM
Zhang QS
Browning BL
Browning SR
Conomos MP
Gogarten SM
Laurie CC
Sofer T
Thornton TA
Hohensee C
Jackson RD
Kooperberg C
Li Y
Méndez-Giráldez R
Perez MV
Peters U
Reiner AP
Zhang ZM
Yao J
Sotoodehnia N
Taylor KD
Guo X
Lange LA
Soliman EZ
Wilson JG
Rotter JI
Heckbert SR
Jain D
Whitsel EA
Source :
Heart rhythm [Heart Rhythm] 2017 Nov; Vol. 14 (11), pp. 1675-1684. Date of Electronic Publication: 2017 Jun 10.
Publication Year :
2017

Abstract

Background: Although time-domain measures of heart rate variability (HRV) are used to estimate cardiac autonomic tone and disease risk in multiethnic populations, the genetic epidemiology of HRV in Hispanics/Latinos has not been characterized.<br />Objective: The purpose of this study was to conduct a genome-wide association study of heart rate (HR) and its variability in the Hispanic Community Health Study/Study of Latinos, Multi-Ethnic Study of Atherosclerosis, and Women's Health Initiative Hispanic SNP-Health Association Resource project (n = 13,767).<br />Methods: We estimated HR (bpm), standard deviation of normal-to-normal interbeat intervals (SDNN, ms), and root mean squared difference in successive, normal-to-normal interbeat intervals (RMSSD, ms) from resting, standard 12-lead ECGs. We estimated associations between each phenotype and 17 million genotyped or imputed single nucleotide polymorphisms (SNPs), accounting for relatedness and adjusting for age, sex, study site, and ancestry. Cohort-specific estimates were combined using fixed-effects, inverse-variance meta-analysis. We investigated replication for select SNPs exceeding genome-wide (P <5 × 10 <superscript>-8</superscript> ) or suggestive (P <10 <superscript>-6</superscript> ) significance thresholds.<br />Results: Two genome-wide significant SNPs replicated in a European ancestry cohort, 1 one for RMSSD (rs4963772; chromosome 12) and another for SDNN (rs12982903; chromosome 19). A suggestive SNP for HR (rs236352; chromosome 6) replicated in an African-American cohort. Functional annotation of replicated SNPs in cardiac and neuronal tissues identified potentially causal variants and mechanisms.<br />Conclusion: This first genome-wide association study of HRV and HR in Hispanics/Latinos underscores the potential for even modestly sized samples of non-European ancestry to inform the genetic epidemiology of complex traits.<br /> (Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1556-3871
Volume :
14
Issue :
11
Database :
MEDLINE
Journal :
Heart rhythm
Publication Type :
Academic Journal
Accession number :
28610988
Full Text :
https://doi.org/10.1016/j.hrthm.2017.06.018