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Heart failure in patients with kidney disease and iron deficiency; the role of iron therapy.
- Source :
-
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia [Nefrologia] 2017 Nov - Dec; Vol. 37 (6), pp. 587-591. Date of Electronic Publication: 2017 Jun 10. - Publication Year :
- 2017
-
Abstract
- Chronic kidney disease and anaemia are common in heart failure (HF) and are associated with a worse prognosis in these patients. Iron deficiency is also common in patients with HF and increases the risk of morbidity and mortality, regardless of the presence or absence of anaemia. While the treatment of anaemia with erythropoiesis-stimulating agents in patients with HF have failed to show a benefit in terms of morbidity and mortality, treatment with IV iron in patients with HF and reduced ejection fraction and iron deficiency is associated with clinical improvement. In a posthoc analysis of a clinical trial, iron therapy improved kidney function in patients with HF and iron deficiency. In fact, the European Society of Cardiology's recent clinical guidelines on HF suggest that in symptomatic patients with reduced ejection fraction and iron deficiency, treatment with IV ferric carboxymaltose should be considered to improve symptoms, the ability to exercise and quality of life. Iron plays a key role in oxygen storage (myoglobin) and in energy metabolism, and there are pathophysiological bases that explain the beneficial effect of IV iron therapy in patients with HF. All these aspects are reviewed in this article.<br /> (Copyright © 2017 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Anemia, Iron-Deficiency drug therapy
Anemia, Iron-Deficiency etiology
Anemia, Iron-Deficiency physiopathology
Animals
Disease Models, Animal
Ferric Compounds administration & dosage
Glomerular Filtration Rate
Heart Failure drug therapy
Hematinics therapeutic use
Humans
Infusions, Intravenous
Iron-Regulatory Proteins deficiency
Iron-Regulatory Proteins physiology
Maltose administration & dosage
Maltose therapeutic use
Meta-Analysis as Topic
Mice
Multicenter Studies as Topic
Practice Guidelines as Topic
Randomized Controlled Trials as Topic
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic physiopathology
Stroke Volume drug effects
Ferric Compounds therapeutic use
Heart Failure etiology
Iron Deficiencies
Maltose analogs & derivatives
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1989-2284
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
- Publication Type :
- Academic Journal
- Accession number :
- 28610806
- Full Text :
- https://doi.org/10.1016/j.nefro.2017.03.027