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Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus.
- Source :
-
Viruses [Viruses] 2017 Jun 13; Vol. 9 (6). Date of Electronic Publication: 2017 Jun 13. - Publication Year :
- 2017
-
Abstract
- The adaptive immune response is necessary for the development of protective immunity against infectious diseases. Porcine reproductive and respiratory syndrome virus (PRRSV), a genetically heterogeneous and rapidly evolving RNA virus, is the most burdensome pathogen of swine health and wellbeing worldwide. Viral infection induces antigen-specific immunity that ultimately clears the infection. However, the resulting immune memory, induced by virulent or attenuated vaccine viruses, is inconsistently protective against diverse viral strains. The immunological mechanisms by which primary and memory protection are generated and used are not well understood. Here, we summarize current knowledge regarding cellular and humoral components of the adaptive immune response to PRRSV infection that mediate primary and memory immune protection against viruses.
- Subjects :
- Animals
Antibodies, Neutralizing
Antibodies, Viral immunology
B-Lymphocytes immunology
Humans
Immunity, Cellular
Immunity, Humoral
Killer Cells, Natural immunology
Mice
Porcine Reproductive and Respiratory Syndrome virology
Swine
T-Lymphocytes immunology
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated immunology
Viral Vaccines administration & dosage
Viral Vaccines immunology
Adaptive Immunity
Immunologic Memory
Porcine Reproductive and Respiratory Syndrome immunology
Porcine respiratory and reproductive syndrome virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 28608816
- Full Text :
- https://doi.org/10.3390/v9060148