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Divergent antiarrhythmic effects of resveratrol and piceatannol in a whole-heart model of long QT syndrome.

Authors :
Ellermann C
Wolfes J
Kochhäuser S
Dechering DG
Reinke F
Wasmer K
Eckardt L
Frommeyer G
Source :
International journal of cardiology [Int J Cardiol] 2017 Sep 15; Vol. 243, pp. 233-238. Date of Electronic Publication: 2017 Jun 03.
Publication Year :
2017

Abstract

Background: The polyphenol resveratrol and its metabolite piceatannol have beneficial health effects including antiarrhythmic properties in ischemia/reperfusion. The objective of this study was to determine potential antiarrhythmic effects in acquired long-QT-syndrome (LQTS).<br />Methods and Results: 26 rabbit hearts were isolated and Langendorff-perfused. The I <subscript>Kr</subscript> -blocker sotalol (100μM) was infused to mimic LQTS-2. Hearts were assigned to two groups. Sotalol significantly prolonged action potential duration (APD <subscript>90</subscript> ) and QT-interval in both groups (group 1:APD <subscript>90</subscript> : +18ms, p<0.01;QT: +59ms, p<0.01; group 2: APD <subscript>90</subscript> : +22ms, p<0.01; QT: +30ms, p<0.01) and also significantly increased dispersion of repolarization (group 1: +21ms, p<0.01; group 2: +23ms, p<0.01). Thereafter, hearts were additionally perfused either with resveratrol (50μM, group 1, n=14) or with piceatannol (10μM, group 2, n=12). Administration of resveratrol significantly reduced APD <subscript>90</subscript> (-29ms, p<0.01), QT-interval(-60ms, p<0.01) and dispersion of repolarization (-26ms, p<0.01). In contrast, piceatannol did not significantly alter APD <subscript>90</subscript> (±0ms) but shortened QT-interval (-19ms, p<0.01) and increased dispersion of repolarization (+15ms, p<0.01). With sotalol, 7 of 14 bradycardic, AV-blocked hearts in group 1 and 8 of 12 in group 2 showed early afterdepolarizations (EAD) after lowering potassium concentration (p<0.01each). Polymorphic ventricular tachycardia (PVT) occurred in 5 of 14 (p<0.05) and 4 of 12 hearts (p=0.09) with a total number of 42 (p<0.05) and 44 episodes (p=0.07), respectively. Additional infusion of resveratrol reduced EAD (2 of 14, p=0.11) and PVT (1 of 14 hearts, p=0.16, 3 episodes, p<0.05). Piceatannol did not suppress EAD or TdP (EAD in 9 of 12 and TdP in 7 of 12 hearts,50 episodes).<br />Conclusion: Resveratrol showed beneficial antiarrhythmic properties in acquired LQTS. Underlying mechanism is a substantial decrease dispersion of repolarization leading to a suppression of triggered activity.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1874-1754
Volume :
243
Database :
MEDLINE
Journal :
International journal of cardiology
Publication Type :
Academic Journal
Accession number :
28606656
Full Text :
https://doi.org/10.1016/j.ijcard.2017.06.005