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Serum alarm antiproteases in systemic sclerosis patients.
- Source :
-
Human immunology [Hum Immunol] 2017 Sep; Vol. 78 (9), pp. 559-564. Date of Electronic Publication: 2017 Jun 09. - Publication Year :
- 2017
-
Abstract
- Alarm antiproteases, i.e. secretory leukocyte protease inhibitor ad elafin, are key mediators in innate immune response and integrate innate and adaptive immunity systems. The aim of the study was to assess clinical significance of serum levels of alarm antiproteases, elafin and secretory leukocyte protease inhibitor (SLPI) in patients with systemic sclerosis (SSc). Twenty-eight patients with SSc, 25 patients with rheumatoid arthritis (RA) and 22 healthy controls were recruited. Serum elafin and SLPI levels were examined using enzyme-linked immunosorbent assay (ELISA). The patients with SSc had significantly increased serum levels of SLPI in comparison with the RA patients and the healthy controls (p<0.01), and the RA patients presented significantly higher serum levels of elafin in comparison with the controls (p=0.003). In the SSc subgroup serum SLPI level negatively correlated with diffusing capacity of the lung for carbon monoxide (DLCO) (r=-0.41, p=0.03) and total lung capacity (r=-0.42, p=0.03). Both alarm antiproteases, elafin and SLPI could be potentially implicated in the pathogenesis of SSc and SLPI may be considered a candidate for serum biomarker of lung involvement in SSc.<br /> (Copyright © 2017. Published by Elsevier Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid diagnosis
Female
Humans
Immunity, Innate
Male
Middle Aged
Scleroderma, Systemic diagnosis
Young Adult
Arthritis, Rheumatoid immunology
Biomarkers blood
Elafin blood
Protease Inhibitors blood
Scleroderma, Systemic immunology
Secretory Leukocyte Peptidase Inhibitor blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1166
- Volume :
- 78
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Human immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28606626
- Full Text :
- https://doi.org/10.1016/j.humimm.2017.06.002