Back to Search
Start Over
Recurrence of vocal fold leukoplakia after carbon dioxide laser therapy.
- Source :
-
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2017 Sep; Vol. 274 (9), pp. 3429-3435. Date of Electronic Publication: 2017 Jun 09. - Publication Year :
- 2017
-
Abstract
- This work aims to analyze the recurrence of vocal fold leukoplakia after carbon dioxide (CO <subscript>2</subscript> ) laser resection. In this retrospective study, all patients undergoing CO <subscript>2</subscript> laser resection of vocal fold leukoplakia were followed up for at least 2 years. Recurrence was diagnosed as any presence of leukoplakia in the vocal cord subsequent to previous successful complete resection. A total of 326 patients with complete resection of vocal fold leukoplakia and follow-up subsequent surveillance laryngoscopy were studied. The recurrence rate, the recurrence time, and risk factors were evaluated. Of these, 52 (16.0%) patients experienced recurrence with a mean follow-up time of 50.5 ± 15.4 months. The mean time to recurrence was 16.2 ± 14.1 months. Univariate analysis showed that the size of lesion (P < 0.001, Pearson χ <superscript>2</superscript> test; P < 0.001, log-rank test) and the pathological grade (P = 0.025, Pearson χ <superscript>2</superscript> test; P = 0.028, log-rank test) were significantly related to recurrence. The size of lesion was an independent prognostic factor for recurrence using multivariate analysis (P = 0.001, logistic regression; P = 0.001, Cox proportional hazards model). Considering the possible recurrence of vocal fold leukoplakia, long-term follow-up is required after CO <subscript>2</subscript> laser resection. In conclusion, the size of lesion combined with the pathological grade are important risk factors that predict vocal fold leukoplakia recurrence.
- Subjects :
- Adult
Aged
Aged, 80 and over
China epidemiology
Female
Follow-Up Studies
Humans
Incidence
Laryngeal Neoplasms diagnosis
Laryngoscopy
Leukoplakia diagnosis
Male
Middle Aged
Neoplasm Recurrence, Local diagnosis
Retrospective Studies
Risk Factors
Vocal Cords diagnostic imaging
Laryngeal Neoplasms surgery
Laser Therapy methods
Lasers, Gas therapeutic use
Leukoplakia surgery
Neoplasm Recurrence, Local epidemiology
Vocal Cords surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1434-4726
- Volume :
- 274
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 28600598
- Full Text :
- https://doi.org/10.1007/s00405-017-4632-6