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Inhibitory Plasticity: Balance, Control, and Codependence.
- Source :
-
Annual review of neuroscience [Annu Rev Neurosci] 2017 Jul 25; Vol. 40, pp. 557-579. Date of Electronic Publication: 2017 Jun 09. - Publication Year :
- 2017
-
Abstract
- Inhibitory neurons, although relatively few in number, exert powerful control over brain circuits. They stabilize network activity in the face of strong feedback excitation and actively engage in computations. Recent studies reveal the importance of a precise balance of excitation and inhibition in neural circuits, which often requires exquisite fine-tuning of inhibitory connections. We review inhibitory synaptic plasticity and its roles in shaping both feedforward and feedback control. We discuss the necessity of complex, codependent plasticity mechanisms to build nontrivial, functioning networks, and we end by summarizing experimental evidence of such interactions.
Details
- Language :
- English
- ISSN :
- 1545-4126
- Volume :
- 40
- Database :
- MEDLINE
- Journal :
- Annual review of neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 28598717
- Full Text :
- https://doi.org/10.1146/annurev-neuro-072116-031005