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General Approach to Five-Membered Nitrogen Heteroaryl C-Glycosides Using a Palladium/Copper Cocatalyzed C-H Functionalization Strategy.
- Source :
-
Organic letters [Org Lett] 2017 Jul 07; Vol. 19 (13), pp. 3608-3611. Date of Electronic Publication: 2017 Jun 09. - Publication Year :
- 2017
-
Abstract
- A general approach to the synthesis of diverse heteroaryl-C-Δ <superscript>1,2</superscript> -glycosides has been developed by employing the Pd(OAc) <subscript>2</subscript> /CuI cocatalyzed direct cross-coupling of five-membered nitrogen heterocycles with 1-iodoglycals in a C-H activation manner. Using this method, 27 examples of heteroaryl-C-Δ <superscript>1,2</superscript> -glycosides, containing indoles, thiazoles, benzothiazoles, imidazoles, benzimidazoles, and benzoxazoles as aglycones were obtained in 43-99% yield.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 19
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 28598174
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b01583