Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report.

Fecal microbiota transplantation (FMT) is a promising strategy that involves reconstruction of gut microbiota. Recently, it has been considered as a treatment of Crohn's disease (CD) and certain neurological diseases. Here, to the best of our knowledge, we report the first case that used FMT to achieve remission of intestinal and neurological symptoms in a girl with CD and a 17-year history of epilepsy. During the 20 mo of follow-up, FMT has proved its efficacy in preventing relapse of seizures after withdrawing the antiepileptic drugs. Furthermore, this finding highlights the role of microbiota-gut-brain axis and inspires a novel treatment for epilepsy through remodeling gut microbiota.
Competing Interests: Conflict-of-interest statement: Zhang FM is a core inventor of the GenFMTer. The other authors have no conflicts of interest to disclose. This case was orally presented by Zhang FM in the 3rd China Holistic Integrative Enterology Conference at May 8, 2016.