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Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction.
- Source :
-
Current vascular pharmacology [Curr Vasc Pharmacol] 2018; Vol. 16 (4), pp. 355-360. - Publication Year :
- 2018
-
Abstract
- Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque.<br />Objective: To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction.<br />Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined.<br />Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003).<br />Conclusion: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Subjects :
- Adult
Aged
Biomarkers blood
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease pathology
Humans
Male
Middle Aged
Rupture, Spontaneous
ST Elevation Myocardial Infarction diagnostic imaging
ST Elevation Myocardial Infarction pathology
ST Elevation Myocardial Infarction surgery
Time Factors
Vitamin D blood
Vitamin D Deficiency diagnosis
Coronary Artery Disease blood
Leptin blood
Matrix Metalloproteinase 2 blood
Plaque, Atherosclerotic
ST Elevation Myocardial Infarction blood
Vitamin D analogs & derivatives
Vitamin D Deficiency blood
Subjects
Details
- Language :
- English
- ISSN :
- 1875-6212
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current vascular pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 28595560
- Full Text :
- https://doi.org/10.2174/1570161115666170609102506