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Cellular immunotherapy of cancer: an overview and future directions.
- Source :
-
Immunotherapy [Immunotherapy] 2017 Jun; Vol. 9 (7), pp. 589-606. - Publication Year :
- 2017
-
Abstract
- The clinical success of checkpoint inhibitors has led to a renaissance of interest in cancer immunotherapies. In particular, the possibility of ex vivo expanding autologous lymphocytes that specifically recognize tumor cells has attracted much research and clinical trial interest. In this review, we discuss the historical background of tumor immunotherapy using cell-based approaches, and provide some rationale for overcoming current barriers to success of autologous immunotherapy. An overview of adoptive transfer of lymphocytes, tumor infiltrating lymphocytes and dendritic cell therapies is provided. We conclude with discussing the possibility of gene-manipulating immune cells in order to augment therapeutic activity, including silencing of the immune-suppressive zinc finger orphan nuclear receptor, NR2F6, as an attractive means of overcoming tumor-associated immune suppression.
- Subjects :
- Animals
Dendritic Cells immunology
Genetic Therapy
Humans
Lymphocyte Activation
Lymphocytes, Tumor-Infiltrating immunology
Neoplasms immunology
RNA Interference
Repressor Proteins
T-Lymphocytes immunology
Tumor Microenvironment
Dendritic Cells transplantation
Immunotherapy, Adoptive methods
Lymphocytes, Tumor-Infiltrating transplantation
Neoplasms therapy
Receptors, Steroid genetics
T-Lymphocytes transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1750-7448
- Volume :
- 9
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 28595516
- Full Text :
- https://doi.org/10.2217/imt-2016-0086