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The IGF-1/Akt/S6 pathway and expressions of glycolytic myosin heavy chain isoforms are upregulated in chicken skeletal muscle during the first week after hatching.
- Source :
-
Animal science journal = Nihon chikusan Gakkaiho [Anim Sci J] 2017 Nov; Vol. 88 (11), pp. 1779-1787. Date of Electronic Publication: 2017 Jun 08. - Publication Year :
- 2017
-
Abstract
- Skeletal muscle mass is an important trait in the animal industry. We previously reported an age-dependent downregulation of the insulin-like growth factor 1 (IGF-1)/Akt/S6 pathway, major protein synthesis pathway, in chicken breast muscle after 1 week of age, despite a continuous increase of breast muscle weight. Myosin heavy chain (HC), a major protein in muscle fiber, has several isoforms depending on chicken skeletal muscle types. HC I (fast-twitch glycolytic type) is known to be expressed in adult chicken breast muscle. However, little is known about the changes in the expression levels of protein synthesis-related factors and HC isoforms in perihatching chicken muscle. In the present study, protein synthesis-related factors, such as IGF-1 messenger RNA (mRNA) levels, phosphorylation of Akt, and phosphorylated S6 content, increased in an age-dependent manner after post-hatch day (D) 0. The mRNA levels of HC I, III and V (fast-twitch glycolytic type) dramatically increased after D0. The increase ratio of breast muscle weight was approximately 1100% from D0 to D7. To our knowledge, these findings provide the first evidence that upregulation of protein synthesis pathway and transcription of fast twitch glycolytic HC isoforms play critical roles in the increase of chicken breast muscle weight during the first week after hatching.<br /> (© 2017 Japanese Society of Animal Science.)
- Subjects :
- Aging genetics
Aging metabolism
Animals
Female
Male
Muscle, Skeletal growth & development
Organ Size genetics
Organ Size physiology
Phosphorylation
Protein Isoforms metabolism
Animals, Newborn genetics
Animals, Newborn metabolism
Chickens genetics
Chickens metabolism
Gene Expression
Insulin-Like Growth Factor I metabolism
Insulin-Like Growth Factor I physiology
Muscle Proteins genetics
Muscle Proteins metabolism
Muscle, Skeletal metabolism
Myosin Heavy Chains genetics
Myosin Heavy Chains metabolism
Protein Biosynthesis genetics
Protein Biosynthesis physiology
Proto-Oncogene Proteins c-akt metabolism
Proto-Oncogene Proteins c-akt physiology
Ribosomal Protein S6 metabolism
Ribosomal Protein S6 physiology
Signal Transduction physiology
Up-Regulation
Subjects
Details
- Language :
- English
- ISSN :
- 1740-0929
- Volume :
- 88
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Animal science journal = Nihon chikusan Gakkaiho
- Publication Type :
- Academic Journal
- Accession number :
- 28594135
- Full Text :
- https://doi.org/10.1111/asj.12847