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Clinicopathological features of cryptococcal lymphadenitis and a review of literature.
- Source :
-
Journal of clinical and experimental hematopathology : JCEH [J Clin Exp Hematop] 2017 Jul 05; Vol. 57 (1), pp. 26-30. Date of Electronic Publication: 2017 Jun 08. - Publication Year :
- 2017
-
Abstract
- Cryptococcosis is an invasive fungal infection in immunocompromised patients. The clinicopathological characteristics of cryptococcal lymphadenitis are not well known. We analyzed three cases of cryptococcal lymphadenitis and compared their characteristics with those in previous reports. Two patients were human immunodeficiency virus (HIV) carriers, and one patient was a human T-cell leukemia virus type-1 (HTLV-1) carrier. The age of the HTLV-1 carrier with cryptococcosis was much higher than that of the HIV-1 carriers. CD4-positive cell counts in peripheral blood were 5.8/μL (Case 1) and 79.9/μL (Case 2) in the HIV carriers and 3285/μL in the HTLV-1 carrier (Case 3). According to flow cytometric analysis of the lymph nodes of Cases 1, 2, and 3, 50.0%, 87.1%, and 85.9%, respectively, of the T-cells were CD3; 9.8%, 16.3%, and 75.8%, respectively, were CD4; and 35.5%, 77.3%, and 10.2%, respectively, were CD8. Cryptococcus neoformans was detected in tissue culture in all patients. Although gelatinous lesions and numerous fungal cocci were observed in the two HIV patients, the granuloma formation was small. Gelatinous formation and granuloma formation were observed in the HTLV-1 carrier. Necrosis was observed in all cases. In previous reports, granuloma formation, epithelioid cells, and necrotic lesions were observed in most cases. Most of the patients were also immunosuppressed. However, no HTLV-1 carrier was detected. In conclusion, lymphadenopathy in a HTLV-1 carrier may suggest the presence of cryptococcal lymphadenitis. The frequency of cryptococcosis in HTVL-1 carriers may increase with increase in the long-term survival rate of HTLV-1 carriers.
- Subjects :
- Adult
Aged, 80 and over
Biomarkers
Biopsy
CD4 Lymphocyte Count
Colony Count, Microbial
Cryptococcosis etiology
Female
HIV Infections complications
HTLV-I Infections complications
Humans
Immunocompromised Host
Lymph Nodes pathology
Lymphadenitis etiology
Male
Phenotype
Cryptococcosis diagnosis
Lymphadenitis diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1880-9952
- Volume :
- 57
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of clinical and experimental hematopathology : JCEH
- Publication Type :
- Academic Journal
- Accession number :
- 28592745
- Full Text :
- https://doi.org/10.3960/jslrt.17011